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KMID : 0371320040670030188
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Journal of the Korean Surgical Society
2004 Volume.67 No. 3 p.188 ~ p.191
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Micrometastasis of Sentinel Lymph Nodes in Gastric Cancer
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Im Tae-Su
Park Won-Cheol
Lee Jeong-Kyun
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Abstract
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PURPOSE: A lymph node metastasis is one of most important prognostic factors of a malignancy. There is a growing interest in the role of the sentinel node (SN) in the detection of lymph node metastasis. However, the high false negative rate of a sentinel lymph node biopsy limits its utility. The aim of this study is to evaluate a micrometastasis of a gastric cancer to the histologically negative sentinel lymph nodes using the usual stains.
METHODS: The SN in 44 out of 57 patients revealed no lymph node metastasis with usual hematoxylin and eosin (H&E) staining. Those nodes were embedded in paraffin and 4-micrometer-thick sections underwent, H&E staining, and cytokeratin immunohisto-chemical (IHC) staining between March 2002 and December 2002.
RESULTS: Micrometastases were detected in 3 of the 44 patients without a SN metastasis. All micrometastases were detected in the patients who had metastases to the non-SN without a SN metastasis (3 of 5, 60%). Micrometastases to the SN were significantly frequent in those patients with a metastasis to the non-SN than those without a metastasis (P<0.001). From the detection of micrometastases, the sensitivity and false-negative rate of a sentinel lymph node biopsy ranged from 72.2% (13/18) to 88.9% (16/18), and from 12.8% (5/39) to 4.9% (2/41), respectively.
CONCLUSION: 3 cases of micrometastasis of the SN without a metastasis were detected, and this increased the sensitivity and decreased the false negative rate of a SN biopsy. Micrometastases of the SNs were detected only in patients with a skip metastasis of the lymph nodes in this study.
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KEYWORD
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